姓名：洪明

性别：男

职称：副研究员

学术兼职：（高校服务国家重大战略出版工程“抗肿瘤中药现代研究与临床应用”编委）

地址：ug环球会员登录先进诊断与先进治疗临床研究中心

E-mail：hongming530[at]126[dot]com

个人简历：

2004.09~2008.07 江西中医药大学生物工程系学习，获生物工程学士学位

2008.07~2011.07军事医学科学院基础医学研究所学习获遗传学硕士学位

2011.07~2011.12 华大基因分子诊断高级专员

2013.01~2013.04 香港大学解剖系研究助理2013.05~2017.09香港大学医学部学习获中药药理学博士学位

2017.12~2020.12广州中医药大学科技创新中心副研究员硕士生导师

2018.06~2018.07  美国堪萨斯大学药理与毒理系访问学者

2021.01~2022.03  广州大学ug环球会员登录生命医学联合研究院独立PI   副研究员

2022.04至今 ug环球会员登录先进诊断与先进治疗临床研究中心 副研究员

主要研究方向（课题）：

　　主要从事中药抗肿瘤活性及其分子机制的研究工作。综合利用网络药理学，分子对接技术以及体内，体外试验预测中药的抗肿瘤活性成分及其分子机制。主要研究方向天然药物抗肿瘤分子机制的研究。

代表性论文、论著和成果：

[1] Ming Hong , Tin Lan, Qiuxia Li, BinfeiLi Yong Yuan, Feng Xu , Weijia Wang. A comprehensive perspective on theinteraction between gut microbiota and COVID-19 vaccines. Gut Microbes. 2023Jan-Dec;15(1):2233146. (IF：12.2)

[2] Li SY, Wang WJ, Li QY, Yang PH, Li XL,Yan Y, Yuan Y, Feng YB, Hong M*. Using omics approaches to dissect thetherapeutic effects of Chinese herbal medicines on gastrointestinal cancers.Front Pharmacol. 2022 Sep 23;13:884822. doi: 10.3389/fphar.2022.884822.eCollection 2022.

[3] Ming Hong*, Mohammed M.Almutairi，Siying Li, Jinke Li* Wogonin inhibits cell cycle progression byactivating the glycogen synthase kinase-3 beta in hepatocellular carcinoma.Phytomedicine. 2020 Jan 18;68:153174.

[4] Bingyu SUN, Yongqiang LIU, Danhua HE,Jinke LI, Jiawei WANG, Wulin WEN*, Ming HONG*, 2021. Traditional Chinesemedicines and their active ingredients sensitizecancer cells to TRAIL-inducedapoptosis. Journal of Zhejiang University-Science B (Biomedicine &Biotechnology), 22(3):190-203(IF:3.1 JCR 2区) (IF：6.543 JCR 1区)

[5] Yi Luo, Yu Feng, Lei Song, Gan-Qing He,Sha Li, Sha-Sha Bai, Yu-Jie Huang, Si-Ying Li, Mohammed M. Almutairi, Hong-LianShi, Qi Wang, Ming Hong*. A network pharmacology-based study on theanti-hepatoma effect of Radix Salviae Miltiorrhizae. Chinese Medicine. 2019; 14

[6] Lei Song, Yi Luo, Yue-xin Wang,Mohammed M.Almutairi, Feng-hua Pan, Rong-wei Li, Qiang yong Liu, Qi Wang*, MingHong*. Exploring the Active Mechanism of Berberine Against HepatocellularCarcinoma by Systematic Pharmacology and Experimental Validation.Molecular  Medicine Reports. 2019 Volume20 Issue 5 https://doi.org/10.3892/mmr.2019.10698  

[7] Hong M#, Shi H#, Wang N, Tan HY, WangQ*, Feng Y* Dual Effects of Chinese Herbal Medicines on Angiogenesis in Cancerand Ischemic Stroke Treatments: Role of HIF-1 Network. Front Pharmacol. 2019Jun 26;10:696. doi: 10.3389/fphar.2019.00696. eCollection 2019.

[8] Ming Hong*#, Zhe Cai#, Lei Song,Yongqiang Liu, Qi Wang* and Xiangfei Feng*. Gynostemma pentaphyllum attenuatesthe progression of Non-alcoholic fatty liver disease in Mice: a biomedicalinvestigation integrated with in silico assay. Evidence-Based Complementary andAlternative Medicine. Volume 2018, Article ID 8384631, 13 pages

[9] Ming Hong*#, Honghui Cheng#, Lei Song,Wencai Wang, Qi Wang, Donggang Xu and Weiwei Xing*. Wogonin Suppresses theActivity of Matrix Metalloproteinase-9 and Inhibits Migration and Invasion inHuman Hepatocellular Carcinoma. Molecules. 2018, 23(2), 384;doi:10.3390/molecules23020384.

[10] Ming Hong#, Yongsheng Zhang#, Sha Li,Hor Yue Tan, Ning Wang, Shuzhen Mu, Xiaojiang Hao，Yibin Feng*. A Network Pharmacology-Based Study on theHepatoprotective Effect of Fructus Schisandrae. Molecules. 2017, 22(10), 1617;doi:10.3390/molecules22101617.

[11] Hong M, Li S, Tan HY, Cheung F, WangN, Huang J, Feng Y*. A Network-Based Pharmacology Study of the Herb-InducedLiver Injury Potential of Traditional Hepatoprotective Chinese HerbalMedicines. Molecules. 2017, 22(4), 632; doi:10.3390/molecules22040632.

[12] Hong M, Li S, Wang N, Tan HY, CheungF, Feng Y*. A Biomedical Investigation on the Hepatoprotective Effect of RadixSalviae Miltiorrhizae and Network pharmacology-based Prediction of the Activecompunds and Molecular Targets. Int. J. Mol. Sci. 2017, 18(3), 620;doi:10.3390/ijms18030620.

[13] Hong M, Tan HY, Li S, Cheung F, Wang NNagamatsu T, Feng Y*. Cancer Stem Cells: The Potential Targets of ChineseMedicines and Their Active Compounds. Int J Mol Sci. 2016. 17(6).  

[14] Hong M, Wang N, Tan HY, Tsao SW, FengY*. MicroRNAs and Chinese Medicinal Herbs: New Possibilities in Cancer Therapy.Cancers (Basel). 2015. 7(3): p. 1643-57.

[15] Ming Hong, Sha Li, Hor Yue Tan, NingWang, Sai-Wah Tsao and Yibin Feng. Current Status of Herbal Medicines inChronic Liver Disease Therapy: The Biological Effects, Molecular Targets andFuture Prospects. Int. J. Mol. Sci. 2015, 16(12), 28705-28745.

[16] Cai Z#, Hong M#, Xu L, Yang K, Li C,Sun T, Feng Y, Zeng H, Lu WW, Chiu KY. Prevent action of magnoflorine withhyaluronic acid gel from cartilage degeneration in anterior cruciate ligamenttransection induced osteoarthritis. Biomed Pharmacother. 2020 Jun;126:109733.

[17] Luo Y, Song L, Wang X, Huang Y, Liu Y,Wang Q, Hong M* and Yuan Z*. Uncovering the Mechanisms of Cryptotanshinone as aTherapeutic Agent Against Hepatocellular Carcinoma. Front. Pharmacol. 11:1264.

[18] Hong M, Zha L, Fu W, Zou M, Li W, XuD. A modified visual loop-mediated isothermal amplification method fordiagnosis and differentiation of main pathogens from Mycobacterium tuberculosiscomplex. World J Microbiol Biotechnol. 2012 Feb;28(2):523-31.

1. 国家自然科学基金（24万），项目编号：820041612021.1-2023.12 负责人：洪明

2.广东省基础与应用基础研究基金项目（10万），项目编号: 2019A15151101672020.1-2021.12 负责人：洪明

3. 2022年度中山市第三批社会公益与基础研究项目（重点项目）（15万）项目编号：20428084378410 2023.1-2024.12负责人：洪明

获得荣誉：

　　香港大学医学部2017届优秀博士论文